|
KMID : 0360120130350010025
|
|
Journal of the Korean Society of Maxillofacial Plastic Reconstructive Surgeons
2013 Volume.35 No. 1 p.25 ~ p.30
|
|
|
Changes of Compound Muscle Action Potential in Short-term Steroid Therapy for Compression Injury of Rat Sciatic Nerve
|
|
Kim So-Hyun
Park Kwang-Won
Baek Joon-Seok
Jung Tae-Young
Kim Mee-Lee
Park Sang-Jun
|
|
|
Abstract
|
|
|
Purpose: Many surgical procedures in oral and maxillofacial area can induce trauma to the peripheral nerve. The aim of the study is to evaluate the effects of short-term steroid therapy on nerve recovery after crush injury.
Methods: Sixteen rats were randomly divided into two groups. The right sciatic nerves were exposed, crushed, and sutured. The control group was not given steroids. The test group was injected with dexamethasone disodium phosphate (2 mg/kg body weight/day) for 7 days. In all animals, compound muscle action potential (CMAP) was recorded before and at 1, 7, 14, 21, and 28 days after injury.
Results: The amplitude of the CMAP before and at 1, 7, 14, 21, and 28 days after injury were $53.20{\pm}4.80$ 수식 이미지 mV, $20.12{\pm}5.38$ 수식 이미지 mV, $30.01{\pm}14.15$ 수식 이미지 mV, $31.14{\pm}13.56$ 수식 이미지 mV, $31.73{\pm}16.33$ 수식 이미지 mV, and $37.23{\pm}16.98$ 수식 이미지 mV in the control group, and $55.25{\pm}6.72$ 수식 이미지 mV, $18.62{\pm}6.26$ 수식 이미지 mV, $29.50{\pm}13.06$ 수식 이미지 mV, $32.90{\pm}13.226$ 수식 이미지 mV, $30.17{\pm}11.80$ 수식 이미지 mV, and $38.41{\pm}12.27$ 수식 이미지 mV in the test group, respectively. The nerve conduction velocity was $18.82{\p 수식 이미지m}3.94$ 수식 이미지 m/s, $16.73{\pm}3.48$ 수식 이미지 m/s, $19.60{\pm}2.45$ 수식 이미지 m/s, $18.68{\pm}3.94$ 수식 이미지 m/s, $18.02{\pm}3.51$ 수식 이미지 m/s, and $19.25{\pm}3.88$ 수식 이미지 m/s in the control group, and $18.94{\pm}3.48$ 수식 이미지 m/s, $17.28{\pm}2.53$ 수식 이미지 m/s, $7.57{\pm}2.54$ 수식 이미지 m/s, $18.77{\pm}2.12$ 수식 이미지 m/s, $19.48{\pm}1.55$ 수식 이미지 m/s, and $19.22{\pm}2.97$ 수식 이미지 m/s in the test group, respectively. There was no significant difference between both groups (P>0.05).3
Conclusion:This study did not show any therapeutic effect of short-term administration of steroids on injured rat sciatic nerve. Further studies are needed.
|
|
|
KEYWORD
|
|
|
Nerve injury, Steroid, Compound muscle action potential
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|